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Article

CALHM2 V136G polymorphism reduces astrocytic ATP release and is associated with depressive symptoms and Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2023

Liao Yang, Wang Yingyi, Tao Qing-Qing, Yang Chaoguang, Wang Jinlei, Cheng Jinbo, Ma Jun, Wu Zhi-Ying, Pan Rui-Yuan, Yuan Zengqiang

Abstract excerpt

INTRODUCTION: Depression is considered a prodromal state of Alzheimer's disease (AD), yet the underlying mechanism(s) by which depression increases the risk of AD are not known. METHODS: Single-nucleotide polymorphism (SNP) analysis was used to determine the CALHM2 variants in AD patients. Cellular and molecular experiments were conducted to investigate the function of CALHM2 V136G mutation. We generated a new...

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PMID: 37493186
DOI: 10.1002/alz.13366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CALHM2 V136G polymorphism reduces astrocytic ATP release and is associated with depressive symptoms and Alzheimer's disease risk.PMID 37493186Read ↗

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