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Article

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.

Cell - 27 Jun 2008

Dreses-Werringloer Ute, Lambert Jean-Charles, Vingtdeux Valérie, Zhao Haitian, Vais Horia, Siebert Adam, Jain Ankit, Koppel Jeremy, Rovelet-Lecrux Anne, Hannequin Didier, Pasquier Florence, Galimberti Daniela, Scarpini Elio, Mann David, Lendon Corinne, Campion Dominique, Amouyel Philippe, Davies Peter, Foskett J Kevin, Campagne Fabien, Marambaud Philippe

Abstract excerpt

Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition. Using TissueInfo to screen for genes preferentially expressed in the hippocampus and located in AD linkage regions, we identified a gene on 10q24.33 that we call CALHM1. We show that CALHM1 encodes a multipass transmembrane glycoprotein that controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18585350
DOI: 10.1016/j.cell.2008.05.048
PMCID: PMC2577842

Genes

CALHM1

Variants

rs2986017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.PMID 18585350Read ↗

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.Semantic proximity Read ↗

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.Semantic proximity Read ↗

Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.Semantic proximity Read ↗

Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population.Semantic proximity Read ↗

A polymorphism in CALHM1 is associated with temporal lobe epilepsy.Semantic proximity Read ↗

No Association between CALHM1 and Alzheimer's Disease RiskSemantic proximity Read ↗

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.Semantic proximity Read ↗

CALHM1 and its polymorphism P86L differentially control Ca²⁺homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β.Semantic proximity Read ↗

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.Semantic proximity Read ↗

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.Semantic proximity Read ↗

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