A polymorphism in CALHM1 is associated with temporal lobe epilepsy.

doi:10.1016/j.yebeh.2011.02.007

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Article

A polymorphism in CALHM1 is associated with temporal lobe epilepsy.

Epilepsy & behavior : E&B - 1 Apr 2011

Lv Rui-juan, He Jin-sheng, Fu Yuan-hui, Shao Xiao-qiu, Wu Li-wen, Lu Qiang, Jin Li-ri, Liu Hui

Abstract excerpt

A recent study suggests that the P86L polymorphism (rs2986017) in the calcium homeostasis modulator 1 (CALHM1) gene interferes with calcium homeostasis and increases amyloid β (Aβ) levels. Moreover, in vitro and in vivo data show that both calcium homeostasis and high levels of Aβ play an important role in the induction and maintenance of epileptic seizures in hippocampus, indicating CALHM1 might play a potential...

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Identifiers

PMID: 21439911
DOI: 10.1016/j.yebeh.2011.02.007

Genes

CALHM1

Variants

rs2986017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism in CALHM1 is associated with temporal lobe epilepsy.PMID 21439911Read ↗

No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population.Semantic proximity Read ↗

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.Semantic proximity Read ↗

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.Semantic proximity Read ↗

Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.Semantic proximity Read ↗

No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population.Semantic proximity Read ↗

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.Semantic proximity Read ↗

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.Semantic proximity Read ↗

Lack of association between CALHM1 p.P86L variation and Alzheimer's disease in the Han Chinese population.Semantic proximity Read ↗

No association between CALHM1 variation and risk of Alzheimer disease.Semantic proximity Read ↗

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.Semantic proximity Read ↗

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