Real-World outcomes of Non-Small cell lung cancer patients harbouring KRAS G12C and KRAS G12D mutations.

doi:10.1016/j.lungcan.2025.108421

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Article

Real-World outcomes of Non-Small cell lung cancer patients harbouring KRAS G12C and KRAS G12D mutations.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2025

Shahnam Adel, Davis Alexander, Brown Lauren Julia, Sullivan Isaac, Lin Kevin, Ng Chien, Yeo Nicholas, Kong Benjamin Y, Khoo Trisha, Warburton Lydia, Da Silva Inês Pires, Mullally William, Xu Wen, O'Byrne Ken, Bray Victoria, Pal Abhijit, Mersaides Antony, Itchins Malinda, Arulananda Surein, Nagrial Adnan, Kao Steven, Alexander Marliese, Lee Chee Khoon, Solomon Benjamin, John Thomas

Abstract excerpt

BACKGROUND: KRAS G12D and G12C mutations have distinct biological traits influencing treatment response. This study examines real-world demographics, clinical characteristics, and first-line treatment outcomes in metastatic non-small-cell lung cancer (NSCLC) patients with these mutations. METHODS: This retrospective, multi-institution observational study used data from the AURORA database. Patients aged 18 years...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Lung Neoplasms

Mutation

Middle Aged

Aged

Retrospective Studies

Treatment Outcome

Adult

Prognosis

Aged, 80 and over

Source

Open in PubMed

Identifiers

PMID: 39977966
DOI: 10.1016/j.lungcan.2025.108421

Genes

KRAS

Variants

Provenance

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