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Article

Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus.

Genes and immunity - 1 Aug 2023

Vazzana Kathleen M, Musolf Anthony M, Bailey-Wilson Joan E, Hiraki Linda T, Silverman Earl D, Scott Christiaan, Dalgard Clifton L, Hasni Sarfaraz, Deng Zuoming, Kaplan Mariana J, Lewandowski Laura B

Abstract excerpt

Childhood-onset systemic lupus erythematosus (cSLE) patients are unique, with hallmarks of Mendelian disorders (early-onset and severe disease) and thus are an ideal population for genetic investigation of SLE. In this study, we use the transmission disequilibrium test (TDT), a family-based genetic association analysis that employs robust methodology, to analyze whole genome sequencing data. We aim to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37488248
DOI: 10.1038/s41435-023-00214-x
PMCID: PMC10529982

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