Article
Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse.
Molecular psychiatry - 1 Oct 2023
Thijssen Anaïs B, Dick Danielle M, Posthuma Danielle, Savage Jeanne E
Abstract excerpt
Alcohol misuse (AM) is highly prevalent and harmful, with theorized subgroups differing on internalizing and externalizing dimensions. Despite known heterogeneity, genome-wide association studies (GWAS) are usually conducted on unidimensional phenotypes. These approaches have identified important genes related to AM but fail to capture a large part of the heritability, even with recent increases in sample sizes....
Topics
- Humans
- Genome-Wide Association Study
- Alcoholism
- Phenotype
- Causality
- Psychopathology