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Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells

24 Jul 2023

Abstract excerpt

The sirtuin enzyme family members, SIRT1 and SIRT2, play both tumor-promoting and tumor-suppressing roles, depending on the context and experimental conditions. Compounds that inhibit either SIRT1 or SIRT2 show promising antitumor effects in several types of cancer models, both in vitro and in vivo . The simultaneous inhibition of SIRT1 and SIRT2 is helpful in treating cancer by completely blocking p53...

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PMID: 37486605
DOI: 10.1021/acs.jcim.3c00556

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