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Article

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines

6 Aug 2018

Abstract excerpt

BACKGROUND: -dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis of HeLa cells. Therefore, selective inhibitors of SIRT2 are candidate therapeutic agents for cancer. Adult T-cell leukemia/lymphoma (ATL) is a T-cell malignancy that has a...

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PMID: 30081901
DOI: 10.1186/s12885-018-4710-1

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