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Treatment of BRAF-V600E mutant metastatic colorectal cancer: new insights and biomarkers.

Expert review of anticancer therapy - 1 Jan 2000

Ros Javier, Rodríguez-Castells Marta, Saoudi Nadia, Baraibar Iosune, Salva Francesc, Tabernero Josep, Élez Elena

Abstract excerpt

INTRODUCTION: The presence of a BRAF-V600E mutation in metastatic colorectal cancer (mCRC) is observed in approximately 12% of cases and is associated with poor prognosis and aggressive disease. Unlike melanoma, the development of successful BRAF blockade in colorectal cancer has been complex. The phase III BEACON trial made significant progress in the development of BRAF inhibitors by establishing...

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PMID: 37482749
DOI: 10.1080/14737140.2023.2236794

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