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Article

BRAF-Mutated Advanced Colorectal Cancer: A Rapidly Changing Therapeutic Landscape.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2022

Ciombor Kristen K, Strickler John H, Bekaii-Saab Tanios S, Yaeger Rona

Abstract excerpt

BRAF-mutated advanced colorectal cancer is a relatively small but critical subset of this tumor type on the basis of prognostic and predictive implications. BRAF alterations in colorectal cancer are classified into three functional categories on the basis of signaling mechanisms, with the class I BRAFV600E mutation occurring most frequently in colorectal cancer. Functional categorization of BRAF mutations in...

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Antineoplastic Combined Chemotherapy Protocols
Cetuximab
Colorectal Neoplasms
Mutation
Protein Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

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PMID: 35649231
DOI: 10.1200/JCO.21.02541
PMCID: PMC9390817

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