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Article

Management of BRAF-mutant metastatic colorectal cancer: a review of treatment options and evidence-based guidelines.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2021

Grothey A, Fakih M, Tabernero J

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is still a leading cause of cancer-related deaths in the United States and worldwide, despite recent improvements in cancer management. CRC, like many malignancies, is a heterogeneous disease, with subtypes characterized by genetic alterations. One common mutation in CRC is in the BRAF gene (most commonly V600E substitution). This occurs in ∼10% of patients with metastatic CRC...

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PMID: 33836264
DOI: 10.1016/j.annonc.2021.03.206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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