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Article

BRAF-Mutated Colorectal Cancer: Clinical and Molecular Insights.

International journal of molecular sciences - 28 Oct 2019

Caputo Francesco, Santini Chiara, Bardasi Camilla, Cerma Krisida, Casadei-Gardini Andrea, Spallanzani Andrea, Andrikou Kalliopi, Cascinu Stefano, Gelsomino Fabio

Abstract excerpt

Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is a heterogeneous disease, which can be classified into different subtypes, characterized by specific molecular and morphological alterations. In this context, BRAF mutations are found in about 10% of CRC patients and define a particular subtype, characterized by a dismal prognosis, with a median survival of less...

Topics

Antineoplastic Combined Chemotherapy Protocols
Bevacizumab
Colorectal Neoplasms
Drug Resistance, Neoplasm
Female
Humans
MAP Kinase Signaling System
Male
Melanoma
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 31661924
DOI: 10.3390/ijms20215369
PMCID: PMC6861966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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