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The Evolving Treatment Landscape in BRAF-V600E-Mutated Metastatic Colorectal Cancer.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting - 1 Apr 2022

Tabernero Josep, Ros Javier, Élez Elena

Abstract excerpt

Between 8% and 12% of patients with metastatic colorectal cancer (mCRC) harbor a BRAF-V600E mutation in their tumors, which is associated with a poor response to standard chemotherapy and short overall survival. Moreover, nearly 30% of BRAF-V600E mCRC tumors also have microsatellite instability. Transcriptomic signatures suggest a strong immunogenic biologic background for most of these tumors. In contrast to the...

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PMID: 35503983
DOI: 10.1200/EDBK_349561

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