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Article

BRAFV600E-Mutant Metastatic Colorectal Cancer: Current Evidence, Future Directions, and Research Priorities.

Clinical colorectal cancer - 1 Sept 2024

Piercey Oliver, Tie Jeanne, Hollande Frederic, Wong Hui-Li, Mariadason John, Desai Jayesh

Abstract excerpt

BRAFV600E-mutant metastatic colorectal cancer represents a distinct molecular phenotype known for its aggressive biological behavior, resistance to standard therapies, and poor survival rates. Improved understanding of the biology of the BRAF oncogene has led to the development of targeted therapies that have paved the way for a paradigm shift in managing this disease. However, despite significant recent...

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Identifiers

PMID: 38816264
DOI: 10.1016/j.clcc.2024.04.004

Genes

BRAF

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