STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.

doi:10.1038/s41419-023-05981-z

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Article

STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.

Cell death & disease - 21 Jul 2023

Li Xinru, Liu Yan, Liu Juan, Qiang Wei, Ma Jingjing, Xie Jingyi, Chen Pu, Wang Yubo, Hou Peng, Ji Meiju

Abstract excerpt

STAG2, an important subunit in cohesion complex, is involved in the segregation of chromosomes during the late mitosis and the formation of sister chromatids. Mutational inactivation of STAG2 is a major cause of the resistance of BRAF-mutant melanomas to BRAF/MEK inhibitors. In the present study, we found that STAG2 was frequently down-regulated in thyroid cancers compared with control subjects. By a series of in...

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PMID: 37479689
DOI: 10.1038/s41419-023-05981-z
PMCID: PMC10361981

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