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Article

Clinical significance of comprehensive genomic profiling in unresectable or recurrent gastrointestinal stromal tumors: a multicenter retrospective cohort study.

Journal of gastroenterology - 1 May 2026

Kawabata Kota, Takahashi Tsuyoshi, Hara Hisashi, Kurokawa Yukinori, Yamamoto Kazuyoshi, Saito Takuro, Akamaru Yusuke, Motoori Masaaki, Nishida Toshirou, Hirota Seiichi, Satoh Taroh, Eguchi Hidetoshi, Doki Yuichiro

Abstract excerpt

BACKGROUND: Tyrosine kinase inhibitors (TKIs) targeting KIT and PDGFRA mutations are the mainstay of treatment for gastrointestinal stromal tumors (GISTs). Comprehensive genomic profiling (CGP) has recently been incorporated into routine practice for various solid tumors, facilitating personalized treatment strategies. We elucidated the current status and clinical significance of CGP in patients with advanced...

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Aged, 80 and over
Clinical Relevance
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Protein Kinase Inhibitors

Proto-Oncogene Proteins c-kit

Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 41266846
DOI: 10.1007/s00535-025-02327-8

Genes

CDKN2A
CDKN2B
KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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