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Article

The Evolving Molecular Landscape of High-Grade Gliomas.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Pinarbasi Emile, Pratt Drew

Abstract excerpt

ABSTRACT: The classification, diagnosis, and biological understanding of high-grade gliomas has been transformed by an evolving understanding of glioma biology. High-grade gliomas, in particular, have exemplified the impact of molecular alterations in pathology. The discovery of mutations in a key metabolic enzyme (IDH), histone genes (H3-3A), and large-scale chromosome changes (+7/-10, 1p/19q) are examples of...

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PMID: 34570447
DOI: 10.1097/PPO.0000000000000542

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