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Article

Glycosphingolipid metabolism and its role in ageing and Parkinson's disease.

Glycoconjugate journal - 1 Feb 2022

Wallom Kerri-Lee, Fernández-Suárez María E, Priestman David A, Te Vruchte Danielle, Huebecker Mylene, Hallett Penelope J, Isacson Ole, Platt Frances M

Abstract excerpt

It is well established that lysosomal glucocerebrosidase gene (GBA) variants are a risk factor for Parkinson's disease (PD), with increasing evidence suggesting a loss of function mechanism. One question raised by this genetic association is whether variants of genes involved in other aspects of sphingolipid metabolism are also associated with PD. Recent studies in sporadic PD have identified variants in multiple...

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Identifiers

PMID: 34757540
DOI: 10.1007/s10719-021-10023-x
PMCID: PMC8979855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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