Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blood lysosphingolipids accumulation in patients with parkinson's disease with glucocerebrosidase 1 mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2018

Pchelina Sofya, Baydakova Galina, Nikolaev Mikhael, Senkevich Konstantin, Emelyanov Anton, Kopytova Alena, Miliukhina Irina, Yakimovskii Andrey, Timofeeva Alla, Berkovich Olga, Fedotova Ekatrina, Illarioshkin Sergey, Zakharova Ekaterina

Abstract excerpt

INTRODUCTION: Glucocerebrosidase 1 mutations, the most common genetic contributor to Parkinson's disease (PD), have been associated with decreased glucocerebrosidase enzymatic activity in PD patients with glucocerebrosidase 1 mutations (glucocerebrosidase 1-PD). However, it is unknown whether this decrease in enzymatic activity leads to lysosphingolipid accumulations. METHODS: The levels of hexosylsphingosines,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucosylceramidase

Share to Mutation

Share to Parkinson Disease

Share to Sphingolipids

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 30192031
DOI: 10.1002/mds.27393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blood lysosphingolipids accumulation in patients with parkinson's disease with glucocerebrosidase 1 mutations.PMID 30192031Read ↗

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s diseaseSemantic proximity Read ↗

Glucocerebrosidase dysfunction in GBA1 carriers: insights from blood and macrophage analyses.Semantic proximity Read ↗

Plasma Glucosylsphingosine in GBA1 Mutation Carriers with and without Parkinson's Disease.Semantic proximity Read ↗

CSF glucosylsphingosine is a central readout of GCase impairment across genetic and sporadic Parkinson’s diseaseSemantic proximity Read ↗

Plasma lysosphingolipids in GRN-related diseases: Monitoring lysosomal dysfunction to track disease progression.Semantic proximity Read ↗

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s diseaseSemantic proximity Read ↗

Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatmentSemantic proximity Read ↗

Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's disease.Semantic proximity Read ↗

The role of glucocerebrosidase in Parkinson disease pathogenesis.Semantic proximity Read ↗

Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.Semantic proximity Read ↗

Plasma Glucosylsphingosine in GBA1 E365K, N409S, and L483P Heterozygous Mutation Carriers.Semantic proximity Read ↗

Serum lipid alterations in GBA-associated Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.