Article
Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease.
Rheumatology (Oxford, England) - 2 May 2024
Williamson Katrina A, Yun Mark, Koster Matthew J, Arment Courtney, Patnaik Asha, Chang Tara W, Bledsoe Adam C, Sae-Tia Sutthichai, Shah Aditya S, Samuels Jonathan, Davis John M, Yao Qingping
Abstract excerpt
OBJECTIVES: Whipple's disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce. Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is an innate immune sensor, resides mainly in monocytes/macrophages and...
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