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Negative regulation of MurZ and MurA underlies the essentiality of GpsB- and StkP-mediated protein phosphorylation in Streptococcus pneumoniae D39.

Molecular microbiology - 1 Sept 2023

Tsui Ho-Ching Tiffany, Joseph Merrin, Zheng Jiaqi J, Perez Amilcar J, Manzoor Irfan, Rued Britta E, Richardson John D, Branny Pavel, Doubravová Linda, Massidda Orietta, Winkler Malcolm E

Abstract excerpt

GpsB links peptidoglycan synthases to other proteins that determine the shape of the respiratory pathogen Streptococcus pneumoniae (pneumococcus; Spn) and other low-GC Gram-positive bacteria. GpsB is also required for phosphorylation of proteins by the essential StkP(Spn) Ser/Thr protein kinase. Here we report three classes of frequently arising chromosomal duplications (≈21-176 genes) containing murZ...

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Identifiers

PMID: 37452010
DOI: 10.1111/mmi.15122
PMCID: PMC10530524

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