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Article

MurA escape mutations uncouple peptidoglycan biosynthesis from PrkA signaling.

PLoS pathogens - 1 Mar 2022

Wamp Sabrina, Rothe Patricia, Stern Daniel, Holland Gudrun, Döhling Janina, Halbedel Sven

Abstract excerpt

Gram-positive bacteria are protected by a thick mesh of peptidoglycan (PG) completely engulfing their cells. This PG network is the main component of the bacterial cell wall, it provides rigidity and acts as foundation for the attachment of other surface molecules. Biosynthesis of PG consumes a high amount of cellular resources and therefore requires careful adjustments to environmental conditions. An important...

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Identifiers

PMID: 35294506
DOI: 10.1371/journal.ppat.1010406
PMCID: PMC8959180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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