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Sublethal β-lactam antibiotics induce PhpP phosphatase expression and StkP kinase phosphorylation in PBP-independent β-lactam antibiotic resistance of <i>Streptococcus pneumoniae</i>

2018-06-08

Abstract excerpt

StkP and PhpP of Streptococcus pneumoniae have been confirmed to compose a signaling couple, in which the former is a serine/threonine (Ser/Thr) kinase while the latter was annotated as a phosphotase. StkP has been reported to be involved in penicillin-binding protein (PBP)-independent penicillin resistance of S. pneumoniae . However, the enzymatic characterization of PhpP and the role of PhpP in StkP-PhpP coupl...

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Literature Corpus work
8ebd6533-5a9d-532f-a606-0601c6b7b545
DOI
10.1101/342188
Open publication

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