Article
High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19.
Viruses - 10 Jun 2022
Cords Leon, Knapp Maximilian, Woost Robin, Schulte Sophia, Kummer Silke, Ackermann Christin, Beisel Claudia, Peine Sven, Johansson Alexandra Märta, Kwok William Wai-Hung, Günther Thomas, Fischer Nicole, Wittner Melanie, Addo Marylyn Martina, Huber Samuel, Schulze Zur Wiesch Julian
Abstract excerpt
Here, we longitudinally assessed the ex vivo frequency and phenotype of SARS-CoV-2 membrane protein (aa145-164) epitope-specific CD4+ T-cells of an anti-CD20-treated patient with prolonged viral positivity in direct comparison to an immunocompetent patient through an MHC class II DRB1*11:01 Tetramer analysis. We detected a high and stable SARS-CoV-2 membrane-specific CD4+ T-cell response in both patients, with...
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