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Article

Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy.

Circulation research - 19 Feb 2010

Chandar Suchitra, Yeo Li Sze, Leimena Christiana, Tan Ju-Chiat, Xiao Xiao-Hui, Nikolova-Krstevski Vesna, Yasuoka Yoshinori, Gardiner-Garden Margaret, Wu Jianxin, Kesteven Scott, Karlsdotter Lina, Natarajan Shweta, Carlton Arthur, Rainer Stephen, Feneley Michael P, Fatkin Diane

Abstract excerpt

RATIONALE: Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A and lamin C, are the most common cause of familial dilated cardiomyopathy (DCM). Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C-deficient hearts, but supporting in vivo evidence has been lacking. OBJECTIVE: Our aim was to study interventions to modify mechanical stress in...

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Source

Identifiers

PMID: 20019332
DOI: 10.1161/CIRCRESAHA.109.204388

Genes

LMNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy.PMID 20019332Read ↗

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Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction.Semantic proximity Read ↗

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs.Semantic proximity Read ↗

Lamin A/C Cardiomyopathy: Implications for Treatment.Semantic proximity Read ↗

Modulation of cytoskeleton in cardiomyopathy caused by mutations in LMNA gene.Semantic proximity Read ↗

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity.Semantic proximity Read ↗

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.Semantic proximity Read ↗

Mutation in lamin A/C sensitizes the myocardium to exercise-induced mechanical stress but has no effect on skeletal muscles in mouse.Semantic proximity Read ↗

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to <i>LMNA</i> cardiomyopathySemantic proximity Read ↗

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Lamin A/C deficiency-mediated ROS elevation contributes to pathogenic phenotypes of dilated cardiomyopathy in iPSC model.Semantic proximity Read ↗

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