Article

Cardiac fibroblasts counterbalance cardiomyocytes in <i>LMNA</i> cardiomyopathy pathogenesis

2025-06-06

Abstract excerpt

Genetic cardiomyopathies arising from mutations in the LMNA gene, encoding nuclear intermediate filaments lamin A/C, display variable age of onset, severity, and fibrosis development. This variability suggests a fundamental element in disease pathogenesis that has yet to be elucidated. Given the central role cardiac fibroblasts play in fibrosis, we explored the relevance of lamin A/C in cardiac fibroblast functio...

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Literature Corpus work: b7375c49-25a3-55ec-aacf-e9aa324a6403
DOI: 10.1101/2025.06.05.657412

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