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Estrogen receptor α-mediated signaling inhibits type I interferon response to promote breast carcinogenesis

1 Jul 2023

Abstract excerpt

Estrogen receptor α (ERα) is an important driver and therapeutic target in ∼70% of breast cancers. How ERα drives breast carcinogenesis is not fully understood. In this study, we show that ERα is a negative regulator of type I interferon (IFN) response. Activation of ERα by its natural ligand estradiol inhibits IFN-β-induced transcription of downstream IFN-stimulated genes (ISGs), whereas ERα deficiency or the...

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PMID: 37442610
DOI: 10.1093/jmcb/mjad047

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