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Article

Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer

6 Jul 2017

Abstract excerpt

Abstract The progesterone receptor (PR) regulates transcriptional programs that drive proliferation, survival, and stem cell phenotypes. Although the role of native progesterone in the development of breast cancer remains controversial, PR clearly alters the transcriptome in breast tumors. This study identifies a class of genes, Interferon (IFN)-stimulated genes (ISGs), potently downregulated by ligand-activated...

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PMID: 28684637
DOI: 10.1158/1541-7786.mcr-17-0180

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