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Article

Elimination of Chromosomal Island SpyCIM1 from Streptococcus pyogenes Strain SF370 Reverses the Mutator Phenotype and Alters Global Transcription.

PloS one - 1 Jan 2015

Hendrickson Christina, Euler Chad W, Nguyen Scott V, Rahman Maliha, McCullor Kimberly A, King Catherine J, Fischetti Vincent A, McShan W Michael

Abstract excerpt

Streptococcus pyogenes chromosomal island M1 (SpyCIM1) integrates by site-specific recombination into the 5' end of DNA mismatch repair (MMR) gene mutL in strain SF370SmR, blocking transcription of it and the downstream operon genes. During exponential growth, SpyCIM1 excises from the chromosome and replicates as an episome, restoring mutL transcription. This process is reversed in stationary phase with SpyCIM1...

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Identifiers

PMID: 26701803
DOI: 10.1371/journal.pone.0145884
PMCID: PMC4689407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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