Article
Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.
Gut - 1 Oct 2011
Miquilena-Colina María Eugenia, Lima-Cabello Elena, Sánchez-Campos Sonia, García-Mediavilla María Victoria, Fernández-Bermejo Miguel, Lozano-Rodríguez Tamara, Vargas-Castrillón Javier, Buqué Xabier, Ochoa Begoña, Aspichueta Patricia, González-Gallego Javier, García-Monzón Carmelo
Abstract excerpt
BACKGROUND: Fatty acid translocase CD36 (FAT/CD36) mediates uptake and intracellular transport of long-chain fatty acids in diverse cell types. While the pathogenic role of FAT/CD36 in hepatic steatosis in rodents is well-defined, little is known about its significance in human liver diseases. OBJECTIVE: To examine the expression of FAT/CD36 and its cellular and subcellular distribution within the liver of...
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