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Article

Associations between TERT Promoter Mutations and Survival in Superficial Spreading and Nodular Melanomas in a Large Prospective Patient Cohort.

The Journal of investigative dermatology - 1 Oct 2022

Chang Gregory A, Robinson Eric, Wiggins Jennifer M, Zhang Yilong, Tadepalli Jyothirmayee S, Schafer Christine N, Darvishian Farbod, Berman Russell S, Shapiro Richard, Shao Yongzhao, Osman Iman, Polsky David

Abstract excerpt

Survival outcomes in melanoma and their association with mutations in the telomerase reverse transcriptase gene TERT promoter remain uncertain. In addition, few studies have examined whether these associations are affected by a nearby common germline polymorphism or vary on the basis of melanoma histopathological subtype. We analyzed 408 primary tumors from a prospective melanoma cohort for somatic TERT-124[C>T]...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35469904
DOI: 10.1016/j.jid.2022.03.031
PMCID: PMC9509439

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