Article
Whole genome sequence analysis of the first Australian OXA-48-producing outbreak-associated Klebsiella pneumoniae isolates: the resistome and in vivo evolution.
PloS one - 1 Jan 2013
Espedido Björn A, Steen Jason A, Ziochos Helen, Grimmond Sean M, Cooper Matthew A, Gosbell Iain B, van Hal Sebastiaan J, Jensen Slade O
Abstract excerpt
Whole genome sequencing was used to characterize the resistome of intensive care unit (ICU) outbreak-associated carbapenem-resistant K. pneumoniae isolates. Importantly, and of particular concern, the carbapenem-hydrolyzing β-lactamase gene bla(OXA-48) and the extended-spectrum β-lactamase gene bla(CTX-M-14), were identified on a single broad host-range conjugative plasmid. This represents the first report of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.