Article

Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells

2023-03-01

Abstract excerpt

Reduced responsiveness of precursor B-acute lymphoblastic leukemia (BCP-ALL) to chemotherapy can be inferred when leukemia cells persist after 28 days of initial treatment. Survival of these long-term persister (LTP) / minimal residual disease (MRD) cells is partly due to bone marrow stromal cells that protect them under conditions of chemotherapy stress. We used RNA-seq to analyse BCP-ALL cells that survived a lo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd2b8f6b-1049-5470-a6c2-f500bb92daa8
DOI: 10.1101/2023.02.28.530540

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cellsDOI 10.1101/2023.02.28.530540Read

Drug-tolerant persister cells in acute myeloid leukemia: pressing challenge and promising new strategies for treatmentSemantic proximity Read

Protracted dormancy of pre-leukemic stem cellsSemantic proximity Read

Drug-tolerant persister cell in cancer: reversibility, microenvironmental interplay, and therapeutic strategiesSemantic proximity Read

Cancer drug-tolerant persister cells: from biological questions to clinical opportunitiesSemantic proximity Read

Mechanism of Drug Tolerant Persister Cancer Cells: The Landscape and Clinical Implication for TherapySemantic proximity Read

Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister CellsSemantic proximity Read

Drug-Tolerant Persister Cells in Cancer Therapy ResistanceSemantic proximity Read

Genome-wide CRISPR screens identify ferroptosis as a novel therapeutic vulnerability in acute lymphoblastic leukemiaSemantic proximity Read

Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemiaSemantic proximity Read

Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic ProgramsSemantic proximity Read

Genome-wide CRISPR Screens Identify Ferroptosis as a Novel Therapeutic Vulnerability in Acute Lymphoblastic LeukemiaSemantic proximity Read

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic LeukemiaSemantic proximity Read