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Article

Rapid detection of fluoroquinolone resistance in Mycobacterium tuberculosis using a novel multienzyme isothermal rapid assay.

The Journal of antibiotics - 1 Oct 2023

Li Ma-Chao, Lu Yao, Liu Hai-Can, Lin Shi-Qiang, Qian Cheng, Nan Xiao-Tian, Li Gui-Lian, Zhao Xiu-Qin, Wan Kang-Lin, Zhao Li-Li

Abstract excerpt

Simple, rapid, and accurate detection of Fluoroquinolone (FQ) resistance is essential for early initiation of appropriate anti-tuberculosis treatment regimen among rifampicin-resistant tuberculosis (RR-TB). In this study, we developed a new assay, which combines multienzyme isothermal rapid amplification and a lateral flow strip (MIRA-LF), to identify the mutations on codons 90 and 94 of gyrA for detecting...

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PMID: 37402884
DOI: 10.1038/s41429-023-00639-6

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