Article
Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts.
International journal of methods in psychiatric research - 1 Dec 2016
Lee Minyoung, Aggen Steven H, Otowa Takeshi, Castelao Enrique, Preisig Martin, Grabe Hans J, Hartman Catharina A, Oldehinkel Albertine J, Middeldorp Christel M, Tiemeier Henning, Hettema John M
Abstract excerpt
To achieve sample sizes necessary for effectively conducting genome-wide association studies (GWASs), researchers often combine data from samples possessing multiple potential sources of heterogeneity. This is particularly relevant for psychiatric disorders, where symptom self-report, differing assessment instruments, and diagnostic comorbidity complicates the phenotypes and contribute to difficulties with...
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