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Article

Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells

2020-12-15

Abstract excerpt

<title>Abstract</title> <p>BackgroundThis study aimed at understanding the effect of metformin on histone H3 modifications at the promoters of cell cycle regulatory genes in lung cancer cells. MethodsHistone H3 modifications were analyzed using ChIP-seq, and changes in DNA methylation and chromatin accessibility were evaluated using the SureSelect Methyl-Seq Target Enrichment System and ATAC-seq, respectively. ML...

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Literature Corpus work
185955ee-f4de-58fa-97d0-7bfab7298fd2
DOI
10.21203/rs.3.rs-125949/v1
Open publication

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