Article
Scn1a and Cacna1a mutations mutually alter their original phenotypes in rats.
Neurochemistry international - 1 Dec 2020
Ohmori Iori, Kobayashi Kiyoka, Ouchida Mamoru
Abstract excerpt
This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a mutants. We investigated general health and the epileptic phenotype in all these genotypes. The onset...
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