Article
Base editor screens for in situ mutational scanning at scale.
Molecular cell - 6 Jul 2023
Lue Nicholas Z, Liau Brian B
Abstract excerpt
A fundamental challenge in biology is understanding the molecular details of protein function. How mutations alter protein activity, regulation, and response to drugs is of critical importance to human health. Recent years have seen the emergence of pooled base editor screens for in situ mutational scanning: the interrogation of protein sequence-function relationships by directly perturbing endogenous proteins in...
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