Article
Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits.
International journal of epidemiology - 1 Dec 2014
Silverwood Richard J, Holmes Michael V, Dale Caroline E, Lawlor Debbie A, Whittaker John C, Smith George Davey, Leon David A, Palmer Tom, Keating Brendan J, Zuccolo Luisa, Casas Juan P, Dudbridge Frank
Abstract excerpt
BACKGROUND: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome. In some cases, however, observational data suggest a non-linear association between exposure and outcome. For example, alcohol consumption is consistently reported as having a U-shaped association with cardiovascular events. In...
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