Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jul 2015

Caulin Aleah F, Graham Trevor A, Wang Li-San, Maley Carlo C

Abstract excerpt

Whales have 1000-fold more cells than humans and mice have 1000-fold fewer; however, cancer risk across species does not increase with the number of somatic cells and the lifespan of the organism. This observation is known as Peto's paradox. How much would evolution have to change the parameters of somatic evolution in order to equalize the cancer risk between species that differ by orders of magnitude in size?...

Topics

Join the communities discussing this publication.

Body Size
Gene Dosage
Genes, Tumor Suppressor
Longevity
Mathematical Concepts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 26056366
DOI: 10.1098/rstb.2014.0222
PMCID: PMC4581027

Genes

FBXO31
MAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis.PMID 26056366Read ↗

Peto’s Paradox: how has evolution solved the problem of cancer prevention?Semantic proximity Read ↗

Natural resistance to cancers in long-lived mammals: genomic mechanisms and experimental evidence to explain Peto's paradox.Semantic proximity Read ↗

Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer.Semantic proximity Read ↗

The Evolution of Human Cancer Gene Duplications across MammalsSemantic proximity Read ↗

From humans to hydra: patterns of cancer across the tree of life.Semantic proximity Read ↗

Mammals and Mutations, Life Span, Cancer Risk.Semantic proximity Read ↗

Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancerSemantic proximity Read ↗

Cancer risk across mammalsSemantic proximity Read ↗

Mechanisms of cancer resistance in long-lived mammals.Semantic proximity Read ↗

Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradoxSemantic proximity Read ↗

Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer–Neurodegeneration ParadoxSemantic proximity Read ↗

Cell size and cancer: a new solution to Peto's paradox?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.