Article
Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance.
Nature communications - 20 Oct 2024
Lin Lianyun, Wang Changshi, Wang Wenlan, Jiang Heng, Murayama Takashi, Kobayashi Takuya, Hadiatullah Hadiatullah, Chen Yu Seby, Wu Shunfan, Wang Yiwen, Korza Henryk, Gu Yucheng, Zhang Yan, Du Jiamu, Van Petegem Filip, Yuchi Zhiguang
Abstract excerpt
The resistance of pests to common insecticides is a global issue that threatens food production worldwide. Diamide insecticides target insect ryanodine receptors (RyRs), causing uncontrolled calcium release from the sarcoplasmic and endoplasmic reticulum. Despite their high potency and species selectivity, several resistance mutations have emerged. Using a chimeric RyR (chiRyR) approach and cryo-electron...
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