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Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

31 Jan 2020

Abstract excerpt

)-one (DNMDP) is a small molecule that kills cancer cells by generation of novel activity. DNMDP induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12) and specifically kills cancer cells expressing elevated levels of these two proteins. Here, we examined the characteristics and covariates of the cancer cell response to DNMDP. On average, the sensitivity of human...

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PMID: 32005668
DOI: 10.1074/jbc.ra119.011191

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