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Article

The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity.

Scientific reports - 17 Dec 2020

Ito Taisei, Inden Masatoshi, Ueda Tomoyuki, Asaka Yuta, Kurita Hisaka, Hozumi Isao

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. Although many drugs have entered clinical trials, few have shown effectiveness in the treatment of ALS. Other studies have shown that the stimulation of α7 nicotinic acetylcholine receptor (nAChR) can have neuroprotective effects in some models of neurodegenerative...

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PMID: 33335227
DOI: 10.1038/s41598-020-79189-y
PMCID: PMC7746719

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