Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health.

doi:10.1177/096228029300200302

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Article

Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health.

Statistical methods in medical research - 1 Jan 1993

Hopper J L

Abstract excerpt

RA Fisher introduced variance components in 1918. He synthesized Mendelian inheritance with Darwin's theory of evolution by showing that the genetic variance of a continuous trait could be decomposed into additive and non-additive components. The model can be extended to include environmental fac...

Topics

Genetic Diseases, Inborn
Genetic Variation
Health Status
History, 20th Century
Humans
Models, Genetic
Models, Statistical
Multivariate Analysis
Pedigree
Social Environment

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