Article
Injury prevents Ras mutant cell expansion in mosaic skin.
Nature - 1 Jul 2023
Gallini Sara, Annusver Karl, Rahman Nur-Taz, Gonzalez David G, Yun Sangwon, Matte-Martone Catherine, Xin Tianchi, Lathrop Elizabeth, Suozzi Kathleen C, Kasper Maria, Greco Valentina
Abstract excerpt
Healthy skin is a mosaic of wild-type and mutant clones1,2. Although injury can cooperate with mutated Ras family proteins to promote tumorigenesis3-12, the consequences in genetically mosaic skin are unknown. Here we show that after injury, wild-type cells suppress aberrant growth induced by oncogenic Ras. HrasG12V/+ and KrasG12D/+ cells outcompete wild-type cells in uninjured, mosaic tissue but their expansion...
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