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Article

HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions.

Journal of clinical immunology - 1 Nov 2022

Cook Sarah, Lenardo Michael J, Freeman Alexandra F

Abstract excerpt

Cells of the innate and adaptive immune systems depend on proper actin dynamics to control cell behavior for effective immune responses. Dysregulated actin networks are known to play a pathogenic role in an increasing number of inborn errors of immunity. The WAVE regulatory complex (WRC) mediates branched actin polymerization, a process required for key cellular functions including migration, phagocytosis,...

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Identifiers

PMID: 35869404
DOI: 10.1007/s10875-022-01327-0
PMCID: PMC9700602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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