Article
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
The New England journal of medicine - 18 Jun 2015
Dobbs Kerry, Domínguez Conde Cecilia, Zhang Shen-Ying, Parolini Silvia, Audry Magali, Chou Janet, Haapaniemi Emma, Keles Sevgi, Bilic Ivan, Okada Satoshi, Massaad Michel J, Rounioja Samuli, Alwahadneh Adel M, Serwas Nina K, Capuder Kelly, Çiftçi Ergin, Felgentreff Kerstin, Ohsumi Toshiro K, Pedergnana Vincent, Boisson Bertrand, Haskoloğlu Şule, Ensari Arzu, Schuster Michael, Moretta Alessandro, Itan Yuval, Patrizi Ornella, Rozenberg Flore, Lebon Pierre, Saarela Janna, Knip Mikael, Petrovski Slavé, Goldstein David B, Parrott Roberta E, Savas Berna, Schambach Axel, Tabellini Giovanna, Bock Christoph, Chatila Talal A, Comeau Anne Marie, Geha Raif S, Abel Laurent, Buckley Rebecca H, İkincioğulları Aydan, Al-Herz Waleed, Helminen Merja, Doğu Figen, Casanova Jean-Laurent, Boztuğ Kaan, Notarangelo Luigi D
Abstract excerpt
Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity in which the T cells that are present are quantitatively or functionally deficient. Impaired humoral immunity is also common. Patients have severe infections, autoimmunity, or both. The specific molecular, cellu...
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