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Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

31 May 2016

Abstract excerpt

Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG. At genome-wide significance level, only ABCA1 harbors associations to both diseases. Here, we investigated the genetic...

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PMID: 27241461
DOI: 10.1038/srep26885

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