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Type 2 Diabetes, Fasting Glucose, Hemoglobin A1c Levels and Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study.

Investigative ophthalmology & visual science - 2 May 2022

Hu Zhao, Zhou Feixiang, Kaminga Atipatsa Chiwanda, Xu Huilan

Abstract excerpt

Purpose: To evaluate the potential causal associations between type 2 diabetes and fasting glucose and HbA1c levels and the risk of primary open-angle glaucoma (POAG) in European and East Asian populations. Methods: We selected genetic variants (P < 5 × 10-8) for type 2 diabetes (898,130 Europeans; 433,540 East Asians), fasting glucose, and HbA1c (196,991 Europeans; 36,584 East Asians) from three meta-analyses of...

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Identifiers

PMID: 35622353
DOI: 10.1167/iovs.63.5.37
PMCID: PMC9150838

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