Article
VARIANTS OF THE FORMATION AND COURSE OF DRUG-RESISTANT EPILEPSY IN CHILDREN WITH GENETIC POLYMORPHISMS OF CYP2C9, CYP2C19, CYP3A4.
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 1 Jan 2023
Tantsura Liudmyla M, Pylypets Olena Yu, Tretiakov Dmytro V, Tantsura Yevhen O
Abstract excerpt
OBJECTIVE: The aim: To clarify the frequency with which various variants of the formation and course of drug-resistant epilepsy occur in children with genetic polymor¬phisms of cytochromes CYP2C9, CYP2C19, CYP3A4. PATIENTS AND METHODS: Materials and methods: The genotyping of CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP3A4*1B by the allele-specific polymerase chain reaction was performed in 116 children with drug-resistant...
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